› 2vv5

X-ray diffraction
3.45Å resolution

The open structure of MscS

Released:
DOI: 10.2210/pdb2vv5/pdb
PDB entry 2vv5 coloured by chain, front view.
PDB entry 2vv5 coloured by chain, side view.
PDB entry 2vv5 coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.
Wang W, Black SS, Edwards MD, Miller S, Morrison EL, Bartlett W, Dong C, Naismith JH, Booth IR
Science 321 1179-83 (2008)
PMID: 18755969

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small-conductance mechanosensitive channel Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 286 amino acids
Theoretical weight: 30.95 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C0S1 (Residues: 1-286; Coverage: 100%)
Gene names: JW2891, b2924, mscS, yggB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 230.88Å b: 126.62Å c: 123.22Å
α: 90° β: 90.42° γ: 90°
R-values:
R R work R free
0.294 0.293 0.312
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Neurosensory mechanotransduction.
Chalfie M. (2009)
28 more

33 mentions without citation

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.
Lundbaek et al. (2010)
32 more