› 2vxd

Solution NMR

The structure of the C-terminal domain of Nucleophosmin

Released:
DOI: 10.2210/pdb2vxd/pdb
PDB entry 2vxd coloured by chain, ensemble of 20 models, front view.
PDB entry 2vxd coloured by chain, ensemble of 20 models, side view.
PDB entry 2vxd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural consequences of nucleophosmin mutations in acute myeloid leukemia.
Grummitt CG, Townsley FM, Johnson CM, Warren AJ, Bycroft M
J Biol Chem 283 23326-32 (2008)
PMID: 18511415

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleophosmin Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 6.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06748 (Residues: 243-294; Coverage: 18%)
Gene names: NPM, NPM1
Sequence domains: Nucleophosmin C-terminal domain
Structure domains: Arc Repressor Mutant, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Ribosomopathies: human disorders of ribosome dysfunction.
Narla et al. (2010)
21 more

10 mentions without citation

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.
Mitrea et al. (2016)
9 more