2w18

X-ray diffraction
1.9Å resolution

Crystal structure of the C-terminal WD40 domain of human PALB2

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for recruitment of BRCA2 by PALB2.
EMBO Rep 10 990-6 (2009)
PMID: 19609323

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-183265 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Partner and localizer of BRCA2 Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 39.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86YC2 (Residues: 835-1186; Coverage: 30%)
Gene names: FANCN, PALB2
Sequence domains: Partner and localizer of BRCA2 WD40 domain
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 80.78Å b: 64.65Å c: 77.25Å
α: 90° β: 109.65° γ: 90°
R-values:
R R work R free
0.211 0.209 0.246
Expression system: Spodoptera frugiperda