› 2wau

X-ray diffraction
3Å resolution

Structure of DBL6 epsilon domain from VAR2CSA

Released:
DOI: 10.2210/pdb2wau/pdb
PDB entry 2wau coloured by chain, front view.
PDB entry 2wau coloured by chain, side view.
PDB entry 2wau coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy.
Khunrae P, Philip JM, Bull DR, Higgins MK
J Mol Biol 393 202-13 (2009)
PMID: 19695262

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte membrane protein 1, PfEMP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 35.63 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I639 (Residues: 2333-2634; Coverage: 10%)
Gene name: PF3D7_1200600
Sequence domains: Duffy binding domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02, ESRF BEAMLINE BM14
Spacegroup: P43212
Unit cell:
a: 62.943Å b: 62.943Å c: 334.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.29 0.289 0.325
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?
Dahlbäck et al. (2010)
8 more

8 mentions without citation

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families.
Higgins et al. (2014)
7 more