› 2wcf

X-ray diffraction
2.78Å resolution

calcium-free (apo) S100A12

Released:
DOI: 10.2210/pdb2wcf/pdb
PDB entry 2wcf coloured by chain, front view.
PDB entry 2wcf coloured by chain, side view.
PDB entry 2wcf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation.
Moroz OV, Blagova EV, Wilkinson AJ, Wilson KS, Bronstein IB
J Mol Biol 391 536-51 (2009)
PMID: 19501594

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A12 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 95 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 45.185Å b: 93.197Å c: 144.532Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.244 0.323
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Functions of S100 proteins.
Donato et al. (2013)
14 more

6 mentions without citation

Binding of transition metals to S100 proteins.
Gilston et al. (2016)
5 more