› 2wnd

X-ray diffraction
1.6Å resolution

Structure of an S100A7 triple mutant

Released:
DOI: 10.2210/pdb2wnd/pdb
PDB entry 2wnd coloured by chain, front view.
PDB entry 2wnd coloured by chain, side view.
PDB entry 2wnd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding.
West NR, Farnell B, Murray JI, Hof F, Watson PH, Boulanger MJ
Protein Sci 18 2615-23 (2009)
PMID: 19844956

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A7 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31151 (Residues: 2-97; Coverage: 95%)
Gene names: PSOR1, S100A7, S100A7C
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I4122
Unit cell:
a: 68.93Å b: 68.93Å c: 92.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.25
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Gross et al. (2014)
3 other articles

3 mentions without citation

Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family.
Wheeler et al. (2016)
2 more