› 2wno

X-ray diffraction
2.3Å resolution

X-ray Structure of CUB_C domain from TSG-6

Released:
DOI: 10.2210/pdb2wno/pdb
PDB entry 2wno coloured by chain, front view.
PDB entry 2wno coloured by chain, side view.
PDB entry 2wno coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.
Briggs DC, Birchenough HL, Ali T, Rugg MS, Waltho JP, Ievoli E, Jowitt TA, Enghild JJ, Richter RP, Salustri A, Milner CM, Day AJ
J Biol Chem 290 28708-23 (2015)
PMID: 26468290

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor-inducible gene 6 protein Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 16.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P98066 (Residues: 129-277; Coverage: 57%)
Gene names: TNFAIP6, TSG6
Sequence domains: CUB domain
Structure domains: Spermadhesin, CUB domain

Ligands and Environments

2 bound ligands:
Ligand CO 1 x CO
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P43212
Unit cell:
a: 56.929Å b: 56.929Å c: 112.572Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.228
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology.
Lord et al. (2020)
3 more

11 mentions without citation

Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains.
González-Calvo et al. (2022)
10 more