› 2wqi

X-ray diffraction
1.7Å resolution

Crystal structure of the human p73 tetramerization domain

Released:
DOI: 10.2210/pdb2wqi/pdb
PDB entry 2wqi coloured by chain, front view.
PDB entry 2wqi coloured by chain, side view.
PDB entry 2wqi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Joerger AC, Rajagopalan S, Natan E, Veprintsev DB, Robinson CV, Fersht AR
Proc Natl Acad Sci U S A 106 17705-10 (2009)
PMID: 19815500

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127444 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein p73 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 51 amino acids
Theoretical weight: 6.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15350 (Residues: 350-399; Coverage: 8%)
Gene names: P73, TP73
Sequence domains: P53 tetramerisation motif
Structure domains: p53-like tetramerisation domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: R3
Unit cell:
a: 76.11Å b: 76.11Å c: 79.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.209 0.254
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Translating p53 into the clinic.
Cheok et al. (2011)
24 more

11 mentions without citation

Classification of intrinsically disordered regions and proteins.
van der Lee et al. (2014)
10 more