› 2wwe

X-ray diffraction
1.25Å resolution

Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma

Released:
DOI: 10.2210/pdb2wwe/pdb
PDB entry 2wwe coloured by chain, front view.
PDB entry 2wwe coloured by chain, side view.
PDB entry 2wwe coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Roos AK, Tresaugues L, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Kallas A, Karlberg T, Kotyenova T, Kotzch A, Kraulis P, Markova N, Moche M, Nielsen TK, Nyman T, Persson C, Schuler H, Schutz P, Siponen MI, Svensson L, Thorsell AG, Van Der Berg S, Wahlberg E, Weigelt J, Welin M, Wisniewska M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75747 (Residues: 1239-1348; Coverage: 7%)
Gene name: PIK3C2G
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3221
Unit cell:
a: 53.42Å b: 53.42Å c: 75.13Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.165 0.184
Expression system: Escherichia coli BL21(DE3)

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