› 2wwf

X-ray diffraction
1.89Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + GMP = ADP + GDP 
ATP + dTMP = ADP + dTDP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 212 amino acids
Theoretical weight: 24.95 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4S1 (Residues: 1-210; Coverage: 100%)
Gene names: PF3D7_1251300, TMK, TMPK
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

4 bound ligands:
Ligand TMP 3 x TMP
Ligand ADP 3 x ADP
Ligand NA 7 x NA
Ligand GOL 9 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 110.127Å b: 110.127Å c: 120.097Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.16 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The Mysterious Multitude: Structural Perspective on the Accessory Subunits of Respiratory Complex I.
Padavannil et al. (2021)
2 more

4 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
3 more