› 2wy1

X-ray diffraction
3.15Å resolution

Crystal structure of rat angiotensinogen in P321 space group

Released:
DOI: 10.2210/pdb2wy1/pdb
PDB entry 2wy1 coloured by chain, front view.
PDB entry 2wy1 coloured by chain, side view.
PDB entry 2wy1 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
A redox switch in angiotensinogen modulates angiotensin release.
Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Broughton Pipkin F, Read RJ
Nature 468 108-11 (2010)
PMID: 20927107

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensinogen Chains: A, B
Molecule details ›
Chains: A, B
Length: 453 amino acids
Theoretical weight: 49.59 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01015 (Residues: 25-477; Coverage: 100%)
Gene names: Agt, Serpina8
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P3221
Unit cell:
a: 133.103Å b: 133.103Å c: 97.185Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.278 0.275 0.327
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease.
Powe et al. (2011)
38 more

2 mentions without citation

A redox switch in angiotensinogen modulates angiotensin release.
Zhou et al. (2010)
1 more