› 2x6l

X-ray diffraction
2.6Å resolution

X-ray Structure of Macrophage Inflammatory Protein-1 beta

Released:
DOI: 10.2210/pdb2x6l/pdb
PDB entry 2x6l coloured by chain, front view.
PDB entry 2x6l coloured by chain, side view.
PDB entry 2x6l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.
Ren M, Guo Q, Guo L, Lenz M, Qian F, Koenen RR, Xu H, Schilling AB, Weber C, Ye RD, Dinner AR, Tang WJ
EMBO J 29 3952-66 (2010)
PMID: 20959807

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo decamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 4 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 69 amino acids
Theoretical weight: 7.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13236 (Residues: 24-92; Coverage: 100%)
Gene names: CCL4, LAG1, MIP1B, SCYA4
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 59.811Å b: 87.892Å c: 186.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.186 0.26
Expression system: Not provided

Quick links

Citations

22 review citations

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
21 more

6 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
5 more