2x7a

X-ray diffraction
2.77Å resolution

Structural basis of HIV-1 tethering to membranes by the Bst2-tetherin ectodomain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-171240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 61 amino acids
Theoretical weight: 6.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q10589 (Residues: 87-147; Coverage: 34%)
Gene name: BST2
Sequence domains: Bone marrow stromal antigen 2
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 169.89Å b: 85.93Å c: 123.31Å
α: 90° β: 126.94° γ: 90°
R-values:
R R work R free
0.238 0.236 0.273
Expression system: Escherichia coli