› 2x82

X-ray diffraction
2.6Å resolution

Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp

Released:
DOI: 10.2210/pdb2x82/pdb
PDB entry 2x82 coloured by chain, front view.
PDB entry 2x82 coloured by chain, side view.
PDB entry 2x82 coloured by chain, top view.
Source organism: Human immunodeficiency virus type 2 (ISOLATE D194)
Primary publication:
Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
Ylinen LM, Price AJ, Rasaiyaah J, Hué S, Rose NJ, Marzetta F, James LC, Towers GJ
PLoS Pathog 6 e1001062 (2010)
PMID: 20808866

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CAPSID PROTEIN P24 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 16.29 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE D194)
Expression system: Escherichia coli
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 47.47Å b: 116.77Å c: 129.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.215 0.28
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Origins of HIV and the AIDS pandemic.
Sharp et al. (2011)
11 more

1 mention without citation

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
Ylinen et al. (2010)