› 2x8l

X-ray diffraction
1.6Å resolution

Plasmodium falciparum lactate dehydrogenase apo structure

Released:
DOI: 10.2210/pdb2x8l/pdb
PDB entry 2x8l coloured by chain, front view.
PDB entry 2x8l coloured by chain, side view.
PDB entry 2x8l coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Birkinshaw RW, Brady RL

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 322 amino acids
Theoretical weight: 34.98 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q71T02 (Residues: 1-316; Coverage: 100%)
Gene names: LDH, LDH-P, ldh
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 80.12Å b: 85.41Å c: 91.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.137 0.136 0.167
Expression system: Escherichia coli

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