› 2xbi

X-ray diffraction
1.6Å resolution

Crystal structure of Schistosoma mansoni Thioredoxin at 1.6 Angstrom

Released:
DOI: 10.2210/pdb2xbi/pdb
PDB entry 2xbi coloured by chain, front view.
PDB entry 2xbi coloured by chain, side view.
PDB entry 2xbi coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Structural and functional characterization of Schistosoma mansoni Thioredoxin.
Boumis G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Miele AE
Protein Sci 20 1069-76 (2011)
PMID: 21465612

Function and Biology Details

Reaction catalysed: 
Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.09 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8T9N5 (Residues: 1-106; Coverage: 100%)
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 39.213Å b: 46.769Å c: 56.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Williams et al. (2013)
4 more

4 mentions without citation

Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography.
Angelucci et al. (2010)
3 more