› 2xdg

X-ray diffraction
1.95Å resolution

Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.

Released:
DOI: 10.2210/pdb2xdg/pdb
PDB entry 2xdg coloured by chain, front view.
PDB entry 2xdg coloured by chain, side view.
PDB entry 2xdg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Quigley A, Barr AJ, Burgess Brown N, Shrestha L, Yang J, Chaikuad A, Vollmar M, Muniz JRC, von Delft F, Edwards A, Arrowsmith CH, Weigelt J, Bountra C, Carpenter EP

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth hormone-releasing hormone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02643 (Residues: 34-123; Coverage: 22%)
Gene name: GHRHR
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain

Ligands and Environments

2 bound ligands:
Ligand MG 3 x MG
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P61
Unit cell:
a: 31.648Å b: 31.648Å c: 287.138Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.165 0.223
Expression system: Spodoptera frugiperda

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