› 2xg7

X-ray diffraction
3.45Å resolution

Crystal Structure of BST2-Tetherin Ectodomain expressed in HEK293T cells

Released:
DOI: 10.2210/pdb2xg7/pdb
PDB entry 2xg7 coloured by chain, front view.
PDB entry 2xg7 coloured by chain, side view.
PDB entry 2xg7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.
Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP
Proc Natl Acad Sci U S A 107 17951-6 (2010)
PMID: 20880831

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone marrow stromal antigen 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 103 amino acids
Theoretical weight: 11.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q10589 (Residues: 51-151; Coverage: 56%)
Gene name: BST2
Sequence domains: Bone marrow stromal antigen 2
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 28.86Å b: 91.86Å c: 146.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.27 0.269 0.298
Expression system: Homo sapiens

Quick links

Citations

23 review citations

HIV Restriction Factors and Mechanisms of Evasion.
Malim et al. (2012)
22 more

5 mentions without citation

Intrinsic cellular defenses against human immunodeficiency viruses.
Blanco-Melo et al. (2012)
4 more