› 2xgo

X-ray diffraction
2.6Å resolution

XcOGT in complex with UDP-S-GlcNAc

Released:
DOI: 10.2210/pdb2xgo/pdb
PDB entry 2xgo coloured by chain, front view.
PDB entry 2xgo coloured by chain, side view.
PDB entry 2xgo coloured by chain, top view.
Source organism: Xanthomonas campestris
Primary publication:
Substrate and product analogues as human O-GlcNAc transferase inhibitors.
Dorfmueller HC, Borodkin VS, Blair DE, Pathak S, Navratilova I, van Aalten DM
Amino Acids 40 781-92 (2011)
PMID: 20640461

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
O-GlcNAc transferase C-terminal domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 568 amino acids
Theoretical weight: 61.42 KDa
Source organism: Xanthomonas campestris
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8PC69 (Residues: 1-568; Coverage: 100%)
Gene name: XCC0866
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZKD 1 x ZKD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 83.656Å b: 100.021Å c: 155.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.259 0.309
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
Huynh et al. (2014)
9 more

2 mentions without citation

Substrate and product analogues as human O-GlcNAc transferase inhibitors.
Dorfmueller et al. (2011)
1 more