2xml

X-ray diffraction
2.55Å resolution

Crystal structure of human JMJD2C catalytic domain

Released:

Function and Biology Details

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) + succinate + formaldehyde + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-190586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 4C Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 40.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H3R0 (Residues: 1-347; Coverage: 33%)
Gene names: GASC1, JHDM3C, JMJD2C, KDM4C, KIAA0780
Sequence domains:
Structure domains: Cupin

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Unit cell:
a: 88.66Å b: 95.87Å c: 100.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.254
Expression system: Escherichia coli BL21(DE3)