› 2xny

X-ray diffraction
7.5Å resolution

A fragment of streptococcal M1 protein in complex with human fibrinogen

Released:
DOI: 10.2210/pdb2xny/pdb
PDB entry 2xny coloured by chain, front view.
PDB entry 2xny coloured by chain, side view.
PDB entry 2xny coloured by chain, top view.
Source organisms:
Primary publication:
Streptococcal M1 protein constructs a pathological host fibrinogen network.
Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P
Nature 472 64-8 (2011)
PMID: 21475196

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
homo dimer
PDBe Complex ID:
PDB-CPX-136001 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Fibrinogen alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 87 amino acids
Theoretical weight: 10.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02671 (Residues: 130-216; Coverage: 10%)
Gene name: FGA
Sequence domains: Fibrinogen alpha/beta chain family
Fibrinogen beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 328 amino acids
Theoretical weight: 37.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02675 (Residues: 164-491; Coverage: 71%)
Gene name: FGB
Sequence domains:
Fibrinogen gamma chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 319 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02679 (Residues: 114-432; Coverage: 75%)
Gene names: FGG, PRO2061
Sequence domains:
M PROTEIN Chains: M, N
Molecule details ›
Chains: M, N
Length: 102 amino acids
Theoretical weight: 12.07 KDa
Source organism: Streptococcus pyogenes
Expression system: Escherichia coli BL21

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P3221
Unit cell:
a: 165.687Å b: 165.687Å c: 289.652Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.423 0.424 0.408
Expression system: Escherichia coli BL21

Quick links

Citations

19 review citations

Fibrinogen as a key regulator of inflammation in disease.
Davalos et al. (2012)
18 more

1 mention without citation

Streptococcal M1 protein constructs a pathological host fibrinogen network.
Macheboeuf et al. (2011)