› 2xoa

X-ray diffraction
2.5Å resolution

Crystal Structure of the N-terminal three domains of the skeletal muscle Ryanodine Receptor (RyR1)

Released:
DOI: 10.2210/pdb2xoa/pdb
PDB entry 2xoa coloured by chain, front view.
PDB entry 2xoa coloured by chain, side view.
PDB entry 2xoa coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule.
Tung CC, Lobo PA, Kimlicka L, Van Petegem F
Nature 468 585-8 (2010)
PMID: 21048710

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 61.97 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11716 (Residues: 1-559; Coverage: 11%)
Gene name: RYR1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: R32
Unit cell:
a: 170.8Å b: 170.8Å c: 301.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.209 0.234
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis.
Priori et al. (2011)
29 more

22 mentions without citation

Ryanodine receptors: structure and function.
Van Petegem F. (2012)
21 more