Function and Biology Details
Reaction catalysed:
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Low-density lipoprotein (LDL) receptor class A repeat
- Serine proteases, trypsin domain
- LDL receptor-like superfamily
- Peptidase S1A, chymotrypsin family
- SRCR domain
- SRCR-like domain superfamily
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
7 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Complement factor I (preferred)
PDBe Complex ID:
PDB-CPX-138563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor I
Molecule details ›
Chains: A, B, C, D
Length: 565 amino acids
Theoretical weight: 63.54 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 565 amino acids
Theoretical weight: 63.54 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P05156 (Residues: 19-583; Coverage: 100%)
Sequence domains:
- Complement factor I, FIMAC N-terminal domain
- Complement factor I, KAZAL domain
- Scavenger receptor cysteine-rich domain
- Low-density lipoprotein receptor domain class A
- Trypsin
