› 2xri

X-ray diffraction
2.15Å resolution

Crystal structure of human ERI1 exoribonuclease 3

Released:
DOI: 10.2210/pdb2xri/pdb
PDB entry 2xri coloured by chain, front view.
PDB entry 2xri coloured by chain, side view.
PDB entry 2xri coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Welin M, Siponen MI, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kol S, Kotenyova T, Kouznetsova E, Moche M, Nyman T, Persson C, Schuler H, Schutz P, Thorsell AG, Tresaugues L, Van Der Berg S, Wahlberg E, Weigelt J, Nordlund P

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERI1 exoribonuclease 3 Chain: A
Molecule details ›
Chain: A
Length: 224 amino acids
Theoretical weight: 25.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43414 (Residues: 137-337; Coverage: 60%)
Gene names: ERI3, PINT1, PRNPIP, PRNPIP1
Sequence domains: Exonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I222
Unit cell:
a: 68.72Å b: 76.9Å c: 86.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.21
Expression system: Escherichia coli BL21(DE3)

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