› 2y25

X-ray diffraction
3.5Å resolution

Crystal structure of the myomesin domains My11-My13

Released:
DOI: 10.2210/pdb2y25/pdb
PDB entry 2y25 coloured by chain, front view.
PDB entry 2y25 coloured by chain, side view.
PDB entry 2y25 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties.
Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M
PLoS Biol 10 e1001261 (2012)
PMID: 22347812

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156477 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myomesin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 35.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52179 (Residues: 1357-1667; Coverage: 19%)
Gene name: MYOM1
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P42
Unit cell:
a: 155.201Å b: 155.201Å c: 106.344Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.266
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The sarcomeric cytoskeleton: from molecules to motion.
Gautel et al. (2016)
4 more

5 mentions without citation

The sarcomeric M-region: a molecular command center for diverse cellular processes.
Hu et al. (2015)
4 more