› 2y78

X-ray diffraction
0.91Å resolution

Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei

Released:
DOI: 10.2210/pdb2y78/pdb
PDB entry 2y78 coloured by chain, front view.
PDB entry 2y78 coloured by chain, side view.
PDB entry 2y78 coloured by chain, top view.
Source organism: Burkholderia pseudomallei K96243
Primary publication:
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.
Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ
Biochem J 437 413-22 (2011)
PMID: 21574961

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.11 KDa
Source organism: Burkholderia pseudomallei K96243
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63J95 (Residues: 1-113; Coverage: 100%)
Gene names: BPSS1823, fbp
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P43212
Unit cell:
a: 54.677Å b: 54.677Å c: 119.172Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.11 0.109 0.116
Expression system: Escherichia coli

Quick links

Citations

2 review citations

FKBP Ligands-Where We Are and Where to Go?
Kolos et al. (2018)
1 more

3 mentions without citation

Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.
Ünal et al. (2014)
2 more