› 2y92

X-ray diffraction
3.01Å resolution

Crystal structure of MAL adaptor protein

Released:
DOI: 10.2210/pdb2y92/pdb
PDB entry 2y92 coloured by chain, front view.
PDB entry 2y92 coloured by chain, side view.
PDB entry 2y92 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.
Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, Kellie S, Sweet MJ, Mansell A, Gay NJ, Martin JL, Kobe B
Proc Natl Acad Sci U S A 108 14879-84 (2011)
PMID: 21873236

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 15.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P58753 (Residues: 79-221; Coverage: 65%)
Gene names: MAL, TIRAP
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

1 bound ligand:
Ligand DTT 1 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 88.146Å b: 88.146Å c: 78.793Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.23 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

27 review citations

Molecular basis of NF-κB signaling.
Napetschnig et al. (2013)
26 more

12 mentions without citation

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
11 more