› 2yad

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145894 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Surfactant protein C Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 171 amino acids
Theoretical weight: 18.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P11686 (Residues: 59-197; Coverage: 71%)
Gene names: SFTP2, SFTPC
Sequence domains:
Structure domains: Enolase-like; domain 1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 54 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 132.046Å b: 39.329Å c: 114.756Å
α: 90° β: 99.63° γ: 90°
R-values:
R R work R free
0.192 0.19 0.222
Expression system: Escherichia coli K-12

Quick links

Citations

20 review citations

Pathogenesis of idiopathic pulmonary fibrosis.
Wolters et al. (2014)
19 more

12 mentions without citation

Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System.
Buxbaum et al. (2017)
11 more