› 2yd1

X-ray diffraction
1.8Å resolution

Crystal structure of the N-terminal Ig1-2 module of Drosophila Receptor Protein Tyrosine Phosphatase DLAR

Released:
DOI: 10.2210/pdb2yd1/pdb
PDB entry 2yd1 coloured by chain, front view.
PDB entry 2yd1 coloured by chain, side view.
PDB entry 2yd1 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR
Science 332 484-8 (2011)
PMID: 21454754

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase Lar Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 23.25 KDa
Source organism: Drosophila melanogaster
Expression system: Homo sapiens
UniProt:
  • Canonical: P16621 (Residues: 33-232; Coverage: 10%)
Gene names: CG10443, Lar
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GLY 1 x GLY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 124.201Å b: 29.074Å c: 49.408Å
α: 90° β: 107.29° γ: 90°
R-values:
R R work R free
0.182 0.18 0.223
Expression system: Homo sapiens

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Citations

74 review citations

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
73 more