› 2yd4

X-ray diffraction
1.65Å resolution

Crystal structure of the N-terminal Ig1-2 module of Chicken Receptor Protein Tyrosine Phosphatase Sigma

Released:
DOI: 10.2210/pdb2yd4/pdb
PDB entry 2yd4 coloured by chain, front view.
PDB entry 2yd4 coloured by chain, side view.
PDB entry 2yd4 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR
Science 332 484-8 (2011)
PMID: 21454754

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase S Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 23.16 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: F1NWE3 (Residues: 29-226; Coverage: 13%)
Gene name: PTPRS
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand CL 1 x CL
Ligand PGE 1 x PGE
Ligand PEG 2 x PEG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: I4122
Unit cell:
a: 104.745Å b: 104.745Å c: 94.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.202
Expression system: Homo sapiens

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Citations

73 review citations

Functional regeneration beyond the glial scar.
Cregg et al. (2014)
72 more

1 mention without citation

Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles et al. (2014)