› 2ywy

X-ray diffraction
2.71Å resolution

Structure of new antigen receptor variable domain from sharks

Released:
DOI: 10.2210/pdb2ywy/pdb
PDB entry 2ywy coloured by chain, front view.
PDB entry 2ywy coloured by chain, side view.
PDB entry 2ywy coloured by chain, top view.
Source organism: Orectolobus maculatus
Primary publication:
Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structures.
Simmons DP, Streltsov VA, Dolezal O, Hudson PJ, Coley AM, Foley M, Proll DF, Nuttall SD
Proteins 71 119-30 (2008)
PMID: 17932913

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108838 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig-like domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 113 amino acids
Theoretical weight: 12.4 KDa
Source organism: Orectolobus maculatus
Expression system: Escherichia coli
UniProt:
  • Canonical: A9CBG4 (Residues: 1-111; Coverage: 100%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 80.498Å b: 88.661Å c: 101.754Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.18 0.27
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Wesolowski et al. (2009)
3 more

1 mention without citation

Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures.
Barroso et al. (2020)