› 2z0q

X-ray diffraction
1.79Å resolution

Crystal structure of DH-PH domain of RhoGEF3(Xpln)

Released:
DOI: 10.2210/pdb2z0q/pdb
PDB entry 2z0q coloured by chain, front view.
PDB entry 2z0q coloured by chain, side view.
PDB entry 2z0q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the Rho-specific guanine nucleotide-exchange factor Xpln.
Murayama K, Kato-Murayama M, Akasaka R, Terada T, Yokoyama S, Shirouzu M
Acta Crystallogr Sect F Struct Biol Cryst Commun 68 1455-9 (2012)
PMID: 23192023

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor 3 Chain: A
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 40.35 KDa
Source organism: Mus musculus
Expression system: Cell free protein synthsis
UniProt:
  • Canonical: Q91X46 (Residues: 110-448; Coverage: 65%)
Gene name: Arhgef3
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 51.582Å b: 62.67Å c: 115.278Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.243
Expression system: Cell free protein synthsis

Quick links

Citations

1 review citation

Role of ARHGEF3 as a GEF and mTORC2 Regulator.
Khaliq et al. (2021)

8 mentions without citation

ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules.
Miceli et al. (2022)
7 more