› 2z5j

X-ray diffraction
3.4Å resolution

Free Transportin 1

Released:
DOI: 10.2210/pdb2z5j/pdb
PDB entry 2z5j coloured by chain, front view.
PDB entry 2z5j coloured by chain, side view.
PDB entry 2z5j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for substrate recognition and dissociation by human transportin 1.
Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, Yamada M, Sato M
Mol Cell 28 57-67 (2007)
PMID: 17936704

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 890 amino acids
Theoretical weight: 101.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-898; Coverage: 99%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P41212
Unit cell:
a: 107.467Å b: 107.467Å c: 194.772Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.232 0.303
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Nuclear import by karyopherin-βs: recognition and inhibition.
Chook et al. (2011)
8 more

4 mentions without citation

How Influenza Virus Uses Host Cell Pathways during Uncoating.
Moreira et al. (2021)
3 more