2z64

X-ray diffraction
2.84Å resolution

Crystal structure of mouse TLR4 and mouse MD-2 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-191589 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Toll-like receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 599 amino acids
Theoretical weight: 67.95 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9QUK6 (Residues: 27-625; Coverage: 74%)
Gene names: Lps, Tlr4
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor
Lymphocyte antigen 96 Chain: C
Molecule details ›
Chain: C
Length: 135 amino acids
Theoretical weight: 15.51 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9JHF9 (Residues: 21-155; Coverage: 95%)
Gene names: Esop1, Ly96, Md2
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, FUL
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 83.158Å b: 101.882Å c: 126.364Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.242 0.29
Expression system: Spodoptera frugiperda