2z65

X-ray diffraction
2.7Å resolution

Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-126150 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
LRRNT domain-containing protein; Toll-like receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.14 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00206 (Residues: 27-228; Coverage: 25%)
  • Canonical: Q4G1L2 (Residues: 126-199; Coverage: 30%)
Gene names: TLR4, VLRB
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Lymphocyte antigen 96 Chains: C, D
Molecule details ›
Chains: C, D
Length: 140 amino acids
Theoretical weight: 16.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y6Y9 (Residues: 19-158; Coverage: 99%)
Gene names: ESOP1, LY96, MD2
Sequence domains: ML domain
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 67.192Å b: 80.987Å c: 107.762Å
α: 90° β: 93.01° γ: 90°
R-values:
R R work R free
0.24 0.238 0.289
Expression system: Spodoptera frugiperda