› 2z6h

X-ray diffraction
2.2Å resolution

Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain

Released:
DOI: 10.2210/pdb2z6h/pdb
PDB entry 2z6h coloured by chain, front view.
PDB entry 2z6h coloured by chain, side view.
PDB entry 2z6h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a full-length beta-catenin.
Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W
Structure 16 478-87 (2008)
PMID: 18334222

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-152831 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 644 amino acids
Theoretical weight: 70.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 138-781; Coverage: 83%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I422
Unit cell:
a: 104.229Å b: 104.229Å c: 259.391Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.249
Expression system: Escherichia coli

Quick links

Citations

35 review citations

The many faces and functions of β-catenin.
Valenta et al. (2012)
34 more

20 mentions without citation

Folding cooperativity and allosteric function in the tandem-repeat protein class.
Perez-Riba et al. (2018)
19 more