› 2z80

X-ray diffraction
1.8Å resolution

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Released:
DOI: 10.2210/pdb2z80/pdb
PDB entry 2z80 coloured by chain, front view.
PDB entry 2z80 coloured by chain, side view.
PDB entry 2z80 coloured by chain, top view.
Source organism: Eptatretus burgeri
Primary publication:
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO
Cell 130 1071-82 (2007)
PMID: 17889651

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 353 amino acids
Theoretical weight: 39.71 KDa
Source organism: Eptatretus burgeri
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60603 (Residues: 1-284; Coverage: 35%)
Gene names: TIL4, TLR2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 54.269Å b: 101.383Å c: 59.586Å
α: 90° β: 99.82° γ: 90°
R-values:
R R work R free
0.22 0.22 0.254
Expression system: Trichoplusia ni

Quick links

Citations

277 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
276 more

20 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
19 more