› 2z81

X-ray diffraction
1.8Å resolution

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Released:
DOI: 10.2210/pdb2z81/pdb
PDB entry 2z81 coloured by chain, front view.
PDB entry 2z81 coloured by chain, side view.
PDB entry 2z81 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO
Cell 130 1071-82 (2007)
PMID: 17889651

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 61.97 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9QUN7 (Residues: 27-506, 509-544; Coverage: 68%)
Gene name: Tlr2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand PCJ 1 x PCJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 83.303Å b: 81.549Å c: 98.961Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.232
Expression system: Trichoplusia ni

Quick links

Citations

278 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
277 more

10 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
9 more