› 2zjw

X-ray diffraction
2.4Å resolution

Crystal structure of human CK2 alpha complexed with Ellagic acid

Released:
DOI: 10.2210/pdb2zjw/pdb
PDB entry 2zjw coloured by chain, front view.
PDB entry 2zjw coloured by chain, side view.
PDB entry 2zjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, Hirasawa A, Tsujimoto G, Tada T
Bioorg Med Chem Lett 19 2920-3 (2009)
PMID: 19414254

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand REF 1 x REF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 47.953Å b: 75.883Å c: 78.421Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.274
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Casein kinases as potential therapeutic targets.
Cozza et al. (2016)
15 other articles

9 mentions without citation

The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design.
Cozza G. (2017)
8 more