› 2zkx

X-ray diffraction
2.72Å resolution

Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121

Released:
DOI: 10.2210/pdb2zkx/pdb
PDB entry 2zkx coloured by chain, front view.
PDB entry 2zkx coloured by chain, side view.
PDB entry 2zkx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yoshikawa S, Kukimoto-Niino M, Ito K, Chen L, Fu ZQ, Chrzas J, Wang BC, Shirouzu M, Urushitani M, Takahashi R, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 159 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00441 (Residues: 1-154; Coverage: 100%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

2 bound ligands:
Ligand CU1 4 x CU1
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: I212121
Unit cell:
a: 73.105Å b: 113.08Å c: 146.375Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.246
Expression system: Escherichia coli

Quick links