› 2zl6

X-ray diffraction
1.43Å resolution

Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus

Released:
DOI: 10.2210/pdb2zl6/pdb
PDB entry 2zl6 coloured by chain, front view.
PDB entry 2zl6 coloured by chain, side view.
PDB entry 2zl6 coloured by chain, top view.
Source organism: Norwalk virus
Primary publication:
Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus.
Choi JM, Hutson AM, Estes MK, Prasad BV
Proc Natl Acad Sci U S A 105 9175-80 (2008)
PMID: 18599458

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182861 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Soluble capsid protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 31.53 KDa
Source organism: Norwalk virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q83884 (Residues: 225-519; Coverage: 56%)
Gene name: ORF2
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL, NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand MG 2 x MG
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 83.512Å b: 83.512Å c: 162.929Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.179 0.2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

43 review citations

Biological roles of glycans.
Varki A. (2017)
42 more

16 mentions without citation

Antiviral targets of human noroviruses.
Prasad et al. (2016)
15 more