› 2zou

X-ray diffraction
1.45Å resolution

Crystal structure of human F-spondin reeler domain (fragment 2)

Released:
DOI: 10.2210/pdb2zou/pdb
PDB entry 2zou coloured by chain, front view.
PDB entry 2zou coloured by chain, side view.
PDB entry 2zou coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop.
Nagae M, Nishikawa K, Yasui N, Yamasaki M, Nogi T, Takagi J
Acta Crystallogr D Biol Crystallogr 64 1138-45 (2008)
PMID: 19020352

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190771 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spondin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HCB6 (Residues: 40-186; Coverage: 19%)
Gene names: KIAA0762, SPON1, VSGP
Sequence domains: Reeler domain
Structure domains: Reeler domain

Ligands and Environments

1 bound ligand:
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 93.253Å b: 50.518Å c: 63.171Å
α: 90° β: 100.37° γ: 90°
R-values:
R R work R free
0.203 0.202 0.222
Expression system: Homo sapiens

Quick links

Citations

4 citation in other articles

Functional importance of covalent homodimer of reelin protein linked via its central region.
Yasui et al. (2011)
3 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)