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TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8

X-ray diffraction
2.83Å resolution
PDB entry 2zpx coloured by chain, front view.
PDB entry 2zpx coloured by chain, side view.
PDB entry 2zpx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble tumor necrosis factor complex
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Multimeric state: homo trimer
Accessible surface area: 17773.39 Å2
Buried surface area: 6520.82 Å2
Dissociation area: 3,260.41 Å2
Dissociation energy (ΔGdiss): 21.25 kcal/mol
Dissociation entropy (TΔSdiss): 24.91 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134285

Macromolecules

Tumor necrosis factor, soluble form
Chains: A, B, C
Length: 157 amino acids
Theoretical weight: 17.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls
Tumor necrosis factor, soluble form in PDB entry 2zpx, assembly 1, front view.
Tumor necrosis factor, soluble form in PDB entry 2zpx, assembly 1, side view.
Tumor necrosis factor, soluble form in PDB entry 2zpx, assembly 1, top view.
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