› 2zt5

X-ray diffraction
2.5Å resolution

Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with ATP)

Released:
DOI: 10.2210/pdb2zt5/pdb
PDB entry 2zt5 coloured by chain, front view.
PDB entry 2zt5 coloured by chain, side view.
PDB entry 2zt5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guo RT, Yang XL, Schimmel P

Function and Biology Details

Reaction catalysed: 
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine--tRNA ligase Chain: A
Molecule details ›
Chain: A
Length: 693 amino acids
Theoretical weight: 78.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41250 (Residues: 55-739; Coverage: 93%)
Gene names: GARS, GARS1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand B4P 1 x B4P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 115.861Å b: 139.84Å c: 132.943Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.258
Expression system: Escherichia coli

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