› 2zt6

X-ray diffraction
3.08Å resolution

Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP

Released:
DOI: 10.2210/pdb2zt6/pdb
PDB entry 2zt6 coloured by chain, front view.
PDB entry 2zt6 coloured by chain, side view.
PDB entry 2zt6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guo RT, Yang XL, Schimmel P

Function and Biology Details

Reaction catalysed: 
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine--tRNA ligase Chain: A
Molecule details ›
Chain: A
Length: 693 amino acids
Theoretical weight: 78.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41250 (Residues: 55-739; Coverage: 93%)
Gene names: GARS, GARS1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand APC 1 x APC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 116.608Å b: 138.862Å c: 133.819Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.244
Expression system: Escherichia coli

Quick links