› 2zv2

X-ray diffraction
2.4Å resolution

Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609

Released:
DOI: 10.2210/pdb2zv2/pdb
PDB entry 2zv2 coloured by chain, front view.
PDB entry 2zv2 coloured by chain, side view.
PDB entry 2zv2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S
J Biol Chem 286 22570-9 (2011)
PMID: 21504895

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.61 KDa
Source organism: Homo sapiens
Expression system: Cell Free Protein Synthesis
UniProt:
  • Canonical: Q96RR4 (Residues: 158-448; Coverage: 50%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 609 1 x 609
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 67.368Å b: 77.153Å c: 84.332Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.252
Expression system: Cell Free Protein Synthesis

Quick links

Citations

3 review citations

Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
Racioppi et al. (2012)
2 more

14 mentions without citation

Characterization of the CaMKKβ-AMPK signaling complex.
Green et al. (2011)
13 more