› 35c8

X-ray diffraction
2Å resolution

CATALYTIC ANTIBODY 5C8, FAB-INHIBITOR COMPLEX

Released:
DOI: 10.2210/pdb35c8/pdb
PDB entry 35c8 coloured by chain, front view.
PDB entry 35c8 coloured by chain, side view.
PDB entry 35c8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for antibody catalysis of a disfavored ring closure reaction.
Gruber K, Zhou B, Houk KN, Lerner RA, Shevlin CG, Wilson IA
Biochemistry 38 7062-74 (1999)
PMID: 10353817

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208561 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.15 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01837 (Residues: 1-104; Coverage: 97%)
Gene name: Igkc
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
IGG 5C8 Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.1 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NOX 1 x NOX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 111.2Å b: 79.9Å c: 65Å
α: 90° β: 118.2° γ: 90°
R-values:
R R work R free
0.206 0.206 0.261

Quick links

Citations

6 review citations

Computational enzyme design.
Kiss et al. (2013)
5 more

2 mentions without citation

Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonization.
Muñoz-Elías et al. (2008)
1 more