› 3a7h

X-ray diffraction
1.96Å resolution

Human MST3 kinase in complex with ATP

Released:
DOI: 10.2210/pdb3a7h/pdb
PDB entry 3a7h coloured by chain, front view.
PDB entry 3a7h coloured by chain, side view.
PDB entry 3a7h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Ko TP, Jeng WY, Liu CI, Lai MD, Wu CL, Chang WJ, Shr HL, Lu TJ, Wang AH
Acta Crystallogr D Biol Crystallogr 66 145-54 (2010)
PMID: 20124694

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 303 amino acids
Theoretical weight: 34.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 10-315; Coverage: 68%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL12B2
Spacegroup: P21
Unit cell:
a: 55.678Å b: 95.194Å c: 61.482Å
α: 90° β: 93.45° γ: 90°
R-values:
R R work R free
0.21 0.204 0.252
Expression system: Escherichia coli

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Citations

2 review citations

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.
Sugden et al. (2013)
1 more

1 mention without citation

A mechanism for localized dynamics-driven activation in Bruton's tyrosine kinase.
Qiu et al. (2021)