› 3a7j

X-ray diffraction
1.5Å resolution

Human MST3 kinase in complex with MnADP

Released:
DOI: 10.2210/pdb3a7j/pdb
PDB entry 3a7j coloured by chain, front view.
PDB entry 3a7j coloured by chain, side view.
PDB entry 3a7j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Ko TP, Jeng WY, Liu CI, Lai MD, Wu CL, Chang WJ, Shr HL, Lu TJ, Wang AH
Acta Crystallogr D Biol Crystallogr 66 145-54 (2010)
PMID: 20124694

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 10-315; Coverage: 68%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand MN 2 x MN
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 47.816Å b: 53.527Å c: 60.634Å
α: 90° β: 109.95° γ: 90°
R-values:
R R work R free
0.191 0.186 0.21
Expression system: Escherichia coli

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Citations

2 review citations

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.
Sugden et al. (2013)
1 more

6 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
5 more