› 3alp

X-ray diffraction
2.8Å resolution

Cell adhesion protein

Released:
DOI: 10.2210/pdb3alp/pdb
PDB entry 3alp coloured by chain, front view.
PDB entry 3alp coloured by chain, side view.
PDB entry 3alp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions.
Narita H, Yamamoto Y, Suzuki M, Miyazaki N, Yoshida A, Kawai K, Iwasaki K, Nakagawa A, Takai Y, Sakisaka T
J. Biol. Chem. 286 12659-69 (2011)
PMID: 21325282

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172234 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 36.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15223 (Residues: 30-335; Coverage: 63%)
Gene names: HVEC, NECTIN1, PRR1, PVRL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CIT 2 x CIT
Ligand HEZ 1 x HEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P213
Unit cell:
a: 164.924Å b: 164.924Å c: 164.924Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.226
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Herpes virus fusion and entry: a story with many characters.
Eisenberg et al. (2012)
8 more

7 mentions without citation

Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.
Di Giovine et al. (2011)
6 more